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Name: | Ibrutinib | Cas: | 936563-96-1 |
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Mf: | C25H24N6O2 | Purity: | 99% |
Appearance: | White Powder | Package: | 1kg/bag Or 25kgs/drum |
High Light: | Active Pharmaceutical Ibrutinib,Anti Cancer Ibrutinib Powder,99.9% Purity Ibrutinib Powder |
Anticancer Active Pharmaceutical Ibrutinib 99.9% Purity Ibrutinib Powder CAS 936563-96-1
CAS No.: | 936563-96-1 |
English Name: | Ibrutinib |
English Alias: | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one /PCI 32765 /CRA-032765 |
Density: | 1.3±0.1 g/cm3 |
Boiling Point: | 715.0±60.0 °C at 760 mmHg |
Melting Point(oC): | N/A |
Molecular Formular: | C25H24N6O2 |
Molecular weight: | 440.497 |
Flash Point: | 386.2±32.9 °C |
Exact Mass: | 440.196075 |
PSA: | 99.16000 |
LogP: | 2.92 |
Vapor pressure: | 0.0±2.3 mmHg at 25°C |
Refractive index: | 1.696 |
Ibrutinib is a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm).
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