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Abt-199 Venclexta CAS 1257044-40-8 For Chronic Lymphocytic Leukemia

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Abt-199 Venclexta CAS 1257044-40-8 For Chronic Lymphocytic Leukemia

Abt-199 Venclexta CAS 1257044-40-8 For Chronic Lymphocytic Leukemia
Abt-199 Venclexta CAS 1257044-40-8 For Chronic Lymphocytic Leukemia

Large Image :  Abt-199 Venclexta CAS 1257044-40-8 For Chronic Lymphocytic Leukemia Get Best Price

Product Details:
Place of Origin: China
Brand Name: germax
Certification: GMP
Model Number: Venclexta
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: Negotiable
Packaging Details: 1kg/bag or 25kgs/drum
Delivery Time: within 3 days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500kgs/week
Detailed Product Description
Name: Venclexta Cas: 1257044-40-8
Mf: C45H50ClN7O7S Purity: 99%
Appearance: White Powder Package: 1kg/bag Or 25kgs/drum
High Light:

Abt-199 Venclexta


1257044-40-8 Venclexta


White Crystalline Venclexta

Venclexta CAS 1257044-40-8 Abt-199 Venclexta for Chronic Lymphocytic Leukemia Cll Original Powder Abt-199

Product NameReady Stock High Purity Venetoclax CAS NO 1257044-40-8 
AppearanceWhite crystalline powder
Molecular formulaC45H50ClN7O7S
Molecular Weight868.44
Shelf Life24 months when properly stored
StorageKeep in a cool, dry, dark location

Product Name: ABT-199
Synonyms: ABT-199;ABT-199 (GDC-0199);GDC-0199;ABT-199 100MG;2-(1H-Pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)met;ABT-199, Venetoclax;ABT-199 (GDC-0199)Venetoclax;4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]ami;Venclexta
CAS: 1257044-40-8
MF: C45H50ClN7O7S
MW: 868.44
EINECS: 820-130-9
ABT-199, also known as venetoclax, is a small, oral chemical molecule used for the treatment of chronic lymphocytic leukemia (CLL) associated with a specific chromosomal abnormality. As a second line treatment drug of CLL, ABT-199 take effects through acting as a BH3-mimetic and inhibitor of Bcl-2 (the anti-apoptotic B-cell lymphoma-2protein), further inducing apoptosis of CLL cells but not platelets. It also has the potential for the treatment of ER-positive breast cancer.


Function of Venetoclax

ABT-199 is a small molecule oral drug that treats chronic lymphocytic leukemia (CLL) in those with a specific chromosomal abnormality.In 2015, the United States Food and Drug Administration (FDA) granted Breakthrough Therapy Designation to venetoclax for subjects with CLL who have relapsed or have been refractory to previous treatment and have the 17p deletion genetic mutation.

Application of Venetoclax

ABT-199 is a white powder, Venetoclax, also known as ABT-199 or GDC0199, ABT-199 is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. ABT-199 mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells.


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