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Name: | Lovastatin | Cas: | 75330-75-5 |
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Mf: | C24H36O5 | Purity: | 99% |
Appearance: | White Powder | Package: | 1kg/bag Or 25kgs/drum |
High Light: | Lovastatin Pharmaceutical Chemicals,75330-75-5 Lovastatin,Antiarrhythmic Lovastatin |
Lovastatin CAS 75330-75-5 Pharmaceutical Chemical Lovastatin for Antiarrhythmic
Product Name | Lovastatin |
CAS | 75330-75-5 |
Appearance | White crystalline powder |
MF | C24H36O5 |
MW | 404.547 |
Purity | 99% |
Shelf Life | 2 Years |
Lovastatin (Merck's Mevacor) is a member of the drug class of statins, used in combination with diet, weight-loss, and exercise for lowering cholesterol (hypolipidemic agent) in those with hypercholesterolemia to reduce risk of cardiovascular disease. Lovastatin is a naturally occurring drug found in food such as oyster mushrooms and red yeast rice.
Lovastatin is a hexahydro naphthalene ester isolated from Aspergillus terreus broth. It is an inactive lactone only yielding activity upon hydrolysis after oral administration. It has a strong competitive inhibition on the HMG-CoA reductase in the liver. HMG-CoA reductase is rate-limiting enzyme for de novo cholesterol synthesis in vivo. The inhibition of the enzyme can block the conversion of HMG-CoA to methacrylic acid, causing significant reduction in cholesterol synthesis, and leading to increased expression of the liver LDL receptor which promotes the plasma LDL-C clearance.
The reduction of cholesterol synthesis can also cause reduced synthesis of liver ApoB100, thus causing that reduction of VLDL synthesis. Clinical observations show that it has a good effect of lowering of plasma total cholesterol and LDLC on hypercholesterolemia caused by various kinds of reasons such as heterozygous familial hypercholesterolemia, polygenic hypercholesterolemia, and diabetes or kidney disease syndrome.
Lovastatin (mevinolin) is a metabolite first isolated from Monascus ruber and later found in several other fungal species. Lovastatin is a potent inhibitor of HMG-CoA. HMG-CoA reductase is the rate-controlling enzyme of the mevalonate pathway, responsible for the biosynthesis of cholesterol. Lovastatin was developed as a drug as a hypolipemic agent.
An antihypercholesterolemic agent. A fungal metabolite,which is a potent inhibitor of HMG-CoA reductase.
Adenosine | AR | 58-61-7 | ≥99% |
Uridine | UR | 58-96-8 | ≥99% |
Cytidine | CR | 65-46-3 | ≥99% |
Xanthosine 5-monophosphate disodium salt | XMP- Na2 | 25899-70-1 | ≥98% |
Inosine-5'-monophosphate disodium salt octahydrate | IMP- Na2 | 20813-76-7 | ≥98% |
Adenosine 5′-monophosphate disodium salt | AMP- Na2 | 4578-31-8 | ≥98% |
Adenosine 5'-Monophosphatesodiumsalt | AMP- Na | .13474-03-8 | ≥98% |
5-Adenylic acid | AMP | 61-19-8 | ≥98% |
Adenosine 3',5'-cyclic monophosphate | Cyclic AMP,CAMP | 60-92-4 | ≥97% |
Uridine 5-monophosphate, disodium salt | UMP- Na2 | 3387-36-8 | ≥98% |
Uridine 5'-monophosphate | UMP | 58-97-9 | ≥98% |
Cytidine 5''-monophosphate disodium salt | CMP- Na2 | .6757-06-8 | ≥98% |
Cytidine 5′-monophosphate | CMP | 63-37-6 | ≥98% |
Citicoline sodium | CDPC-Na | 33818-15-4 | ≥98% |
uridine 5'-diphosphate disodium salt | UDP-Na2 | 27821-45-0 | ≥95% |
IDP-K2 | ≥90% | ||
Inosine-5'-diphosphoric acid disodium salt | IDP-Na2 | 54735-61-4 | ≥90% |
Cytidine 5'-Diphosphate Trisodium Salt Hydrate | CDP-Na3 | 34393-59-4 | ≥90% |
Cytidine-5'-diphosphate disodium salt | CDP-Na2 | 54394-90-0 | ≥90% |
Adenosine 5'-diphosphate dipotassiuM salt | ADP-K2 | 114702-55-5 | ≥95% |
Adenosine-5'-diphosphate, MonopotassiuM salt | ADP-K | 72696-48-1 | ≥95% |
Adenosine-5-diphosphate disodium salt | ADP-Na2 | 16178-48-6 | ≥95% |
Adenosine 5''-diphosphate sodium salt | ADP-Na | 20398-34-9 | ≥95% |
Adenosine 5''-diphosphate | ADP | 58-64-0 | ≥95% |
Uridine 5'-triphosphate disodium salt | UTP-Na3 | 19817-92-6 | ≥90% |
Uridine-5'-triphosphoric acid trisodium salt | UTP-Na2 | 285978-18-9 | ≥90% |
CTP-Na3 | ≥95% | ||
Cytidine 5′-triphosphate disodium salt | CTP-Na2 | 36051-68-0 | ≥95% |
Adenosine 5'-triphosphate disodium salt | ATP-Na2 | 987-65-5 | ≥95% |
Adenosin-5'-triphosphat | ATP | 56-65-5 |
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