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API 99% Eribulin Mesylate CAS 441045-17-6 Chemical Raw Material

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API 99% Eribulin Mesylate CAS 441045-17-6 Chemical Raw Material

API 99% Eribulin Mesylate CAS 441045-17-6 Chemical Raw Material
API 99% Eribulin Mesylate CAS 441045-17-6 Chemical Raw Material

Large Image :  API 99% Eribulin Mesylate CAS 441045-17-6 Chemical Raw Material Get Best Price

Product Details:
Place of Origin: China
Brand Name: germax
Certification: GMP
Model Number: Eribulin Mesylate
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: Negotiable
Packaging Details: 1kg/bag or 25kgs/drum
Delivery Time: within 3 days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500kgs/week
Detailed Product Description
Name: Eribulin Mesylate Cas: 441045-17-6
Mf: C8H17NO2 Purity: 99%
Appearance: White Powder Package: 1kg/bag Or 25kgs/drum
High Light:

API 99% Eribulin Mesylate


441045-17-6 Chemical Raw Material


C8H17NO2 Eribulin Mesylate

API 99%Min Eribulin Mesylate CAS 441045-17-6 Raw Material Powder Anticancer Eribulin Mesylate




The U.S. FDA approved eribulin mesylate (also referred to as E7389) in November 2010 for the treatment of metastatic breast cancer (MBC) for patients who previously received at least two chemotherapeutic regimens for late-stage disease. Eribulin is a synthetic analog of the marine natural product halichondrin B, which is isolated from the sea sponge Halichondria okadai. Eribulin retains most of the structural elements that constitute the right hand side of halichondrin B; structure-activity relationship (SAR) studies suggested that the antitumor activity of halichondrin B resides in that part of the molecule . Eribulin is a microtubule inhibitor that binds close to the vinca-binding site of tubulin. Unlike most tubulin inhibitors like taxanes, epothilones, and vinca alkaloids that inhibit microtubule dynamic instability by changing tubulin addition and loss parameters, eribulin's effects on dynamic instability are novel in that eribulin inhibits the growth phase of microtubules without affecting the shortening phase by binding to microtubule plus ends.


Product Name: Eribulin Mesylate
Synonyms: Halaven;Eribulin mesylate Halaven;Eribulin Mesilate
CAS: 441045-17-6
MF: C40H59NO11.CH4O3S
MW: 729.89656
Product Categories: API
Molecular Structure:  


A methanesulfonate salt obtained by reaction of eribulin with one equivalent of methanesulfonic acid. A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mecha ism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage.




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