CAS 72559-06-9 Medical Rifabutine Chemical Raw Materials For Anti Tuberculosis

Rifabutine CAS 72559-06-9 Ansatipine Mycobutin Medical High Quality Rifabutin Mycobutin for Anti-Tuberculosis

Product Name: Rifabutin
Synonyms: 4-Deoxw3,4-[2-spiro(N-isobutyl-4-pipendyl)]-(1H)-imidazo-(2,5-dihydro)rifamycin S;4-N-ISOBUTYLSPIROPIPERIDYLRIFAMYCIN S;RIFABUTIN;RIFABUTINE;1,4-dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxo-rifamycinxi;(9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-6,16,18,20-Tetrahydroxy-1'-isobutyl-14-methoxy-7,9,15,17,19,21,25-hepta-methyl-spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo-[2',3':7,8]-naphth[1,2-d]imidazol-2,4'-piperidin]-5,10,26-(3H,9H)-trione;Ansatipine;Mycobutin
CAS: 72559-06-9
MF: C46H62N4O11
MW: 847
EINECS: 615-780-3

Melting point: 169-171°C
Boiling point: 329.1±15.0 °C
Density: 1.137±0.06 g/cm3
Storage temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
Appearance: Red-Brown Powder

Description:

Rifabutin, a rifamycin antibacterial derivative, is the first agent approved and introduced for the prevention of Mycobacterium avium complex (MAC) in AIDS patients. It is also indicated in combination chemotherapy for the prophylaxis and treatment of MAC infections in HIV positive patients and for newly diagnosed and chronic tuberculosis.

Uses:

Rifamycins are antibiotics that inhibit DNA-dependent RNA polymerases and are usually bactericidal against Gram-positive bacteria but bacteriostatic against Gram-negative bacteria. Rifamycins are also effective against Mycobacterium species, including M. tuberculosis. Rifabutin is a broad-spectrum rifamycin antibiotic that has applications against tuberculosis, H. pylori, M. avium complex, Chlamydia, and other bacteria. It is also useful in co-infections with human immunodeficiency virus, including tuberculosis.

Application:
It is a spiral-piperidine derivative of rifamycin, and its inhibitory effect on Mycobacterium tuberculosis is about 4 times stronger than that of rifamycin. Mainly used for divergent bacilli pulmonary infection, effective for rifampicin resistant tuberculosis bacilli strains, can be used for drug resistance, relapse tuberculosis cases, intracellular divergent bacilli infection and the treatment of AIDS.