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Pharmaceutical Azilsartan Medoxomil CAS 863031-21-4 For Hypertension

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Pharmaceutical Azilsartan Medoxomil CAS 863031-21-4 For Hypertension

Pharmaceutical Azilsartan Medoxomil CAS 863031-21-4 For Hypertension
Pharmaceutical Azilsartan Medoxomil CAS 863031-21-4 For Hypertension

Large Image :  Pharmaceutical Azilsartan Medoxomil CAS 863031-21-4 For Hypertension Get Best Price

Product Details:
Place of Origin: China
Brand Name: germax
Certification: GMP
Model Number: Azilsartan Medoxomil
Payment & Shipping Terms:
Minimum Order Quantity: 100 gram
Price: Negotiable
Packaging Details: 1kg/bag or 25kgs/drum
Delivery Time: within 24 hours after get the payment
Payment Terms: Western Union, MoneyGram, T/T
Supply Ability: 500KG/week
Detailed Product Description
Name: Azilsartan Medoxomil Appearance: White Powder
CAS: 863031-21-4 Package: Aluminum Foil Bag
Production Capacity: 500 Kilogram/month Storage: Kept In A Cool,dry And Ventilated Place
Purity: 99% MF: C30H24N4O8
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Pharmaceutical Azilsartan Medoxomil


Azilsartan Medoxomil CAS 863031-21-4


Hypertension Azilsartan Medoxomil

Supply Pharmaceutical Azilsartan Medoxomil CAS 863031-21-4 Azilsartan for Hypertension



Product Name: Azilsartan Medoxomil
Synonyms: 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-, (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester;Azilsaran medoxomil;(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-+oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate;1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzim;1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;Azilsartan medoxomil;TAK 491;CS-306
CAS: 863031-21-4
MF: C30H24N4O8
MW: 568.53
EINECS: 1308068-626-2
Product Categories: Azilsartan Medoxomil;Inhibitors




Azilsartan medoxomil (Edarbi), an angiotensin II receptor antagonist, was approved by the U.S. FDA in February 2011 for the treatment of hypertension in adults. The discovery of azilsartan was the result of a medicinal chemistry effort to identify an ARB with a different carboxylic acid isostere than the ones found in the marketed ARBs. Several of the marketed ARBs use a tetrazole group as a carboxylic acid isostere. The medicinal chemistry approach that led to azilsartan involved the replacement of this commonly used tetrazole with a 5-oxo-1,2,4-oxadiazole group. Azilsartan can be synthesized by Suzuki coupling of p-tolyl boronic acid to 2-bromobenzonitrile, followed by bromination of the methyl group. The bromide is displaced to introduce a protected 2-ethoxy-1H-benzo[d] imidazole-7-carboxylate. The cyano group is converted to a hydroxylamidine, followed by reaction with an alkyl-chloroformate and intramolecular cyclization to form the 5-oxo-1,2,4-oxadiazole ring. The acid is then deprotected and converted to a prodrug. The parent, azilsartan has been extensively characterized in vitro and compared with other marketed AT1 antagonists olmesartan, valsartan, telmisartan, irbesartan, and candesartan. Azilsartan was found to be a potent (IC50=2.6 nM), selective, inverse agonist of the AT1 receptor. From washout experiments, azilsartan was found have slow dissociation from the receptor and thus is characterized as an insurmountable antagonist.



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