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| Name: | Palonosetron Hydrochloride | Cas: | 135755-51-0 |
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| Mf: | C19H24N2O.HCl | Purity: | 99% |
| Appearance: | White Powder | Package: | 1kg/bag Or 25kgs/drum |
| High Light: | Palonosetron Hydrochloride,135755-51-0 Palonosetron Hydrochloride,White Powder Palonosetron Hydrochloride |
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Big Discount Purity 99% Palonosetron Hydrochloride CAS 135755-51-0 with Best Quality
Product Name: Palonosetron Hydrochloride
Synonyms: (S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5;Palonosetron hydrochloride, 99.5%, a 5-HT3 antagonist;PALONOSETRON HCL;PALONOSETRON HYDROCHLORIDE;CS-292;Palonosetronhydrochloride hydrochloride;Palonosetron-d3 HCl;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride
CAS: 135729-62-3
MF: C19H25ClN2O
MW: 332.87
EINECS: 680-630-6
Melting point: >290°C
Storage temp.: Refrigerator
Description:
Palonosetron hydrochloride is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention.
Usage:
Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
| Batch No. | HF210420 | Quantity | 2.2kgs |
| Mfg. Date | Apr. 20, 2021 | Package | As required |
| Rep. Date | Apr. 23, 2021 | Exp. Date | Apr. 19, 2023 |
| Items | Standards | Results | |
| Appearance | White or off-white crystalline powder | Complies | |
| Identification | By IR | Complies | |
| By HPLC | Complies | ||
| Solubility | Freely soluble in water, soluble in methanol and 0.1mol/L hydrochloric acid solution,hardly soluble in isopropyl alcohol | Complies | |
| Clarity&Color of Solution | Clear and Colourless | Complies | |
| Specific Rotation | -93°~-103° | -94.4° | |
| R,R-Isomer | ≤ 0.02% | ND | |
| pH | 4.5~6.0 | 5.69 | |
| Sulfate | ≤ 0.06% | Complies | |
| Chloride(on dried basis) | 9.6%~11.7% | 10.7% | |
| Loss on Drying | ≤ 0.50% | 0.10% | |
| Heavy Metals | ≤ 10ppm | Complies | |
| Residue on Ignition | ≤ 0.10% | 0.06% | |
| Residual Solvents | Methanol: ≤3000ppm | ND | |
| Ethanol: ≤5000ppm | 600 | ||
| Diethyl ether: ≤5000ppm | ND | ||
| Tetrahydrofuran: ≤720ppm | ND | ||
| Ethyl acetate: ≤5000ppm | ND | ||
| Isopropanol: ≤5000ppm | ND | ||
| Chloroform: ≤60ppm | ND | ||
| Toluene: ≤890ppm | ND | ||
| N,N-Dimethylformamide: ≤880ppm | ND | ||
| Related Substances | Diastereomer: ≤0.10% | 0.003% | |
| Nitrogen oxides: ≤0.10% | 0.006% | ||
| Other individual impurity: ≤0.10% | ND | ||
| Total Impurities: ≤0.50% | 0.01% | ||
| Assay (on the anhydrous basis) | 99.0%~101.0% | 99.46% | |
| Reference Standard | In-house Standard | ||
| Conclusion | The product complied to In-house standard. | ||
| Storage | Preserve in tight, light-resistant containers in a cool place | ||
Contact Person: July
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