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Vildagliptin Antidiabetic Active Pharmaceutical Ingredient CAS 274901-16-5

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Vildagliptin Antidiabetic Active Pharmaceutical Ingredient CAS 274901-16-5

Vildagliptin Antidiabetic Active Pharmaceutical Ingredient CAS 274901-16-5
Vildagliptin Antidiabetic Active Pharmaceutical Ingredient CAS 274901-16-5

Large Image :  Vildagliptin Antidiabetic Active Pharmaceutical Ingredient CAS 274901-16-5 Get Best Price

Product Details:
Place of Origin: China
Brand Name: germax
Certification: GMP
Model Number: Vildagliptin
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: Negotiable
Packaging Details: 1kg/bag or 25kgs/drum
Delivery Time: within 3 days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500kgs/week
Detailed Product Description
Name: Vildagliptin Cas: 274901-16-5
Mf: C17H25N3O2 Purity: 99%
Appearance: White Powder Package: 1kg/bag Or 25kgs/drum
High Light:

Antidiabetic Active Pharmaceutical Ingredient


274901-16-5 Vildagliptin Api Chemical


Vildagliptin Active Pharmaceutical Ingredient

Vildagliptin for Antidiabetic 99.6% Purity Raw Material Vildagliptin Powder CAS 274901-16-5 Vildagliptin


Product name Vildagliptin
Cas No. 274901-16-5
Molecular Formula C17H25N3O2
Appearance White powder

Vildagliptin (LAF-237; NVP-LAF 237) inhibits DPP-4 with IC50 of 2.3 nM.IC50 Value: 2.3 nM.Target: DPP-4in vitro: Vildagliptin is an N-substituted glycyl-2-cyanopyrrolidine (figure 2). It is a potent competitive and reversible inhibitor of human and rodent DPP-4 in vitro, with a median inhibitory concentration (IC50) ~2-3 nmol/L. Importantly, vildagliptin inhibits DPP-4 with high specificity relative to other similar peptidases where its IC50 exceeds 200 mol/ vivo: Compared to age-, gender-, BMI-matched subjects with normal renal function, the mean AUC of vildagliptin after 14 days in patients with mild, moderate, and severe RI increased by 40%, 71%, and 100%, respectively. The treatment was effective in modulating stress in pancreatic tissue, both by reducing levels of stress markers as well as by increasing activity of SOD and catalase. After analyzing the pancreatic histology, we found that vildagliptin was also able to preserve islets and pancreatic β-cells, especially at the concentration of 5 mg/kg.



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