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| NAME: | Levonorgestrel | CAS: | 797-63-7 |
|---|---|---|---|
| Purity: | 99% | MF: | C21H28O2 |
| Color: | White Powder | Package: | 1kg/bag Or 25kgs/drum |
| High Light: | Levonorgestrel Pharmaceutical Raw Materials,797-63-7 Levonorgestrel Powder,Oral Contraception Levonorgestrel Powder |
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Factory Price 99% Pharmaceutical Raw Material CAS 797-63-7 Levonorgestrel
| Product Name | Levonorgestrel |
| CAS. | 797-63-7 |
| Molecular Weight | 312.45 |
| Molecular Formula | C21H28O2 |
| EINECS | 212-349-8 |
| Melting point | 206°C |
| Boiling point | 392.36°C (rough estimate) |
Certificate of Analysis
| Items | Specification | Results |
| Description | White or practically white crystalline powder | White crystalline powder |
| Specific Rotation | 30°~-35° | 32° |
| Melting Range | 232~239°C, and melting range is not more then 4°C | 234~238°C |
| identification | It complies with the test for specific optical rotation and melting point | Conforms |
| Infrared absorption spectrophotometry should be consistent with levonorgestrel CRS | Conforms | |
| Loss on drying | ≤0.5% | 0.20% |
| Residue on ignition | ≤0.3% | 0.07% |
| Limit of Ethynyl Group | 7.81%~8.18% | 7.92% |
| Related substances | Single impurity ≤0.5% | single impurity<0.5% |
| Total Impurities ≤2.0% | Total impurities<2.0% | |
| Organic Volatile impurties | Ethanol ≤5000ppm | 1200ppm |
| Assay | The product complies with specification in USP34 | |
| Particle Size | D(0.9)<10μm | |
| Storage Condition | Sealed, protect from light |
1. Oral contraception
At low doses, levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250 μ G, and triphasic doses of 50 μ G/75 μ G/125 μ G.
At very low daily dose of 30 μ G, levonorgestrel is used in some progestogen only pill formulations.
2. Emergency contraception
Levonorgestrel is used in emergency contraceptive pills (ECPs), both in a combined Yuzpe regimen which includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5 mg (as a single dose or as two 0.75 mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 hours (5 days) after intercourse could be effective.
3. Intrauterine system
Levonorgestrel is the active ingredient in the Mirena & Skyla (Jaydess) intrauterine system.
4. Contraceptive implants
Levonorgestrel is the active ingredient in Norplant and Jadelle.
5. Hormone replacement therapy
Levenorgestrel is combined with 17-beta estradiol in the Climara Pro hormonal patch.
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