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CAS 202138-50-9 Tenofovir Disoproxil Fumarate Pharma Raw Materials For Treat Aids

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CAS 202138-50-9 Tenofovir Disoproxil Fumarate Pharma Raw Materials For Treat Aids

CAS 202138-50-9 Tenofovir Disoproxil Fumarate Pharma Raw Materials For Treat Aids
CAS 202138-50-9 Tenofovir Disoproxil Fumarate Pharma Raw Materials For Treat Aids

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Product Details:
Place of Origin: China
Brand Name: germax
Certification: GMP
Model Number: Tenofovir Disoproxil Fumarate
Payment & Shipping Terms:
Minimum Order Quantity: 100 grams
Price: Negotiable
Packaging Details: 1kg/bag or 25kgs/drum
Delivery Time: within 3 days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500kgs/week
Detailed Product Description
Name: Tenofovir Disoproxil Fumarate Cas: 202138-50-9
Appearance: White Powder Purity: 99%
Package: 1kg/carton; 25kg/drum Standard: USP/EP/CP/BP
Storage: Keep In Dark And Dry Place MF: C23H34N5O14P
High Light:

Tenofovir Disoproxil Fumarate


202138-50-9 Pharma Raw Materials


C23H34N5O14P Pharma Raw Materials

Tenofovir Disoproxil Fumarate CAS 202138-50-9 for Treat Aids Pharma Raw Materials



1. Description

Tenofovir disoproxil is an antiretroviral medication used to prevent and treat HIV/AIDS and to treat chronic hepatitis B. The active substance is tenofovir, while tenofovir disoproxil is a prodrug that is used because of its better absorption in the gut.

The drug is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is marketed by Gilead Sciences under the trade name Viread(as the fumarate, TDF). As of 2015 the cost for a typical month of medication in the United States is more than 200 USD.

2. Medical Applciation

HIV-1 infection: Tenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older.[5] This indication is based on analyses of plasma HIV-1 RNA levels and CD4 cell counts in controlled studies of tenofovir in treatment-naive and treatment-experienced adults.

Tenofovir is indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.


3. Tenofovir Disoproxil Fumarate(TDF)


Food Interactions: None

Very well tolerated, side effects are minimal.


Renal insufficiency(rare)

Must dose adjust with renal failure.

Also has activity against Hepatitis B.

Dosed 300mg QD.

Active against Lamivudine resistant HBV strains.

HBV resistance 1% at one year.

If TDF is stopped, may have HBV hepatitis flare.


Specification Sheet (COA)


Product name Tenofovir Disoproxil Fumarate CAS no. 202138-50-9
Items Specifications Results
Appearance A White to off white crystalline powder White crystalline powder
Solubility Freely soluble in DMF and in methanol,sparingly soluble in water Conform
Identification A). By IR: Positive Conform
B). By HPLC: Positive Conform
Residue on ignition 0.2% max complies
Water(By K.F) 1.0% max 0.4%
Heavy metals 20ppm max Conform
Related Substance
(by HPLC)
a (Tenofovir): 0.15% max Not detected
b (Adenine): 0.15% max Not detected
c (Tenofovir isoproxil monoester): 1.0% max 0.29%
d (Tenofovir Disoproxil ethyl ester):0.15 max Not detected
e (Tenofovir isopropyl isoproxil ): 0.3% max Not detected
f (Tenofovir Disoproxil carbamate):0.15% max Not detected
g (Tenofovir Disoproxil Dimer):0.15% Not detected
Any Individual unspecified impuriy:0.1% 0.09%
Total impurity: 2.0% max 0.40%
Enantiomeric Purity 1.0% max Not detected
Tenofovir Disoproxil Related compound B 5PPM max Not detected
Fumaric Acid 17.5~19.0% 18.03%
Residual solvents Ethanol: 5000ug/g max 1159ug/g
Isopropyl alcohol: 5000ug/g max 1077ug/g
Methylene chloride: 600ug/g max Not detected
NMP: 530ug/g max Not detected
Assay (on anhydrous basis) 98.0% to 102.0% 99.25%

Comply with USP34


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