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| Name: | Fipronil | Cas: | 120068-37-3 |
|---|---|---|---|
| Mf: | C12H4Cl2F6N4OS | Content: | 99% |
| Appearance: | White Powder | Package: | 5kgs/bottle |
| Quality Standard: | CP,USP | ||
| High Light: | Insecticide Fipronil,Pesticide Fipronil,Agrochemical Fipronil Powder |
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Agrochemical Pesticide Insecticide Fipronil CAS 120068-37-3 High quality Fipronil
| Fipronil Basic information |
| Product Name: | Fipronil |
| Synonyms: | 4-((trifluoromethyl)sulfinyl)-;m&b46030;PRINCE;REGENT;FIPRONIL;5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile;FIPRONIL <)>97 % (HPLC, EFF.);Goliath gel |
| CAS: | 120068-37-3 |
| MF: | C12H4Cl2F6N4OS |
| MW: | 437.15 |
| EINECS: | 424-610-5 |
| Product Categories: | Pesticides intermediate;Fipronil insecticidal spectrum is wide, and existing insecticide resistance without interaction;Pesticide intermediates;NULL;MYCODECYL;Agro-Products;Heterocycles;PHARMACEUTICALS;Baby Food Directives 13/2003 EC&14/2003 ECPesticides&Metabolites;AcaricidesMethod Specific;Alpha sort;E-GAlphabetic;European Community: ISO and DIN;F;FA - FLPesticides;Insecticides;Pesticides;Pesticides&Metabolites;Pyrazoles;Ectoparasiticide;API;INSECTICIDE |
| Mol File: | 120068-37-3.mol |
| Fipronil Chemical Properties |
| Melting point | 200-201°C |
| Boiling point | 510.1±50.0 °C(Predicted) |
| density | 1.477-1.626 |
| vapor pressure | 3.7×10-7 Pa (25 °C) |
| storage temp. | 0-6°C |
| Water Solubility | 1.9-2.4 mg 1l-1 (20 °C) |
| form | neat |
| pka | -5.86±0.20(Predicted) |
| λmax | 208nm(H2O)(lit.) |
| Merck | 14,4085 |
| BRN | 8090115 |
| CAS DataBase Reference | 120068-37-3(CAS DataBase Reference) |
| EPA Substance Registry System | Fipronil (120068-37-3) |
| Safety Information |
| Hazard Codes | T,N |
| Risk Statements | 23/24/25-48/25-50/53-55-57-36 |
| Safety Statements | 26-36/37/39-45-60-61-36/37-28 |
| RIDADR | 2588 |
| WGK Germany | 3 |
| RTECS | UQ4430250 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29331990 |
| Hazardous Substances Data | 120068-37-3(Hazardous Substances Data) |
| Toxicity | LD50 in rats (mg/kg): 100 orally; >2000 dermally (Colliot); in mice (mg/kg): 32 i.p. (Cole) |
| MSDS Information |
| Provider | Language |
|---|---|
| 5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile | English |
| Fipronil Usage And Synthesis |
| Description | Fipronil is a white powder with a mouldy odour. It has a low solubility in water and is a slow-acting poison. It does not bind strongly with soil, and the half-life of fipronil- sulphone is 34 days. Fipronil is a broadspectrum insecticide of the phenylpyrazole group. Fipronil was first used extensively for the control of ants, beetles, cockroaches, fleas; ticks, termites, mole crickets, thrips, rootworms, weevils, flea of pets, field pest of corn, golf courses, and commercial turf, and other insects. Fipronil was first used in the United States in 1996. Fipronil is a topical insecticide. It kills adult fleas and larvae, ticks, and chewing lice. As a liquid, fipronil is applied on the back side skin of dogs and cats. Reports indicate that some animals do become hypersensitive (allergic) to fipronil. |
| Chemical Properties | White crystalline solid. |
| Chemical Properties | White SOlid |
| Uses | antifungal |
| Uses | Pesticide. |
| Uses | A broad spectrum insecticide which actively disrupts the CNS of contacted insects by blocking the passage of chloride ions through GABA receptors. |
| Uses | Fipronil is used for the control of a wide range of insect species in rice, cereals, corn, cotton, top fruit, sugar beet, sugar cane, oilseed rape, many vegetables and other high-value crops. It also has a veterinary use as an ectoparasiticide. |
| Agricultural Uses | Insecticide, Veterinary medicine: Not approved for use in EU countries. Fipronil was introduced into the U.S. in 1996 for use in animal health and indoor pest control. It is the constituent of many products for controlling a wide spectrum of domestic animal and residential pests. |
| Trade name | BES® 602; CEASEFIRE®; CHIPCO®; COMBAT®; FRONTLINE; MB-46030®; H&G®; ICON®; MAXFORCE® ANT STATION; MAXFORCE® ROACH STATION; REGENCY SOFION®; REGENT®; REGENT® 500-FS; TERMIDOR® L VI-NIL |
| Pharmacology | Fipronil is a phenylpyrazole, the mode of action of which is to inhibit nerve transmission in arthropods by blocking γ -aminobutyric acid-gated chloride channels. Fipronil is available as spray and spot-on formulations to control fleas and ticks on cats and dogs. The adulticidal activity of fipronil accounts for the majority of its activity, although additional activity against flea eggs and larvae results from the presence of fipronil on hairs and debris shed into the environment from treated pets. Autohistoradiography studies (11) into the cutaneous distribution of 14C-fipronil in the cat and dog following spot-on administration demonstrated that radioactivity was restricted principally to the stratum corneum, the viable epidermis, and the pilosebaceous units. Following its slow release from sebaceous glands, fipronil migrates in the sebum covering the skin and hairs by passive diffusion and was shown to persist on hair for up to 2 months after treatment. |
| Potential Exposure | Pyrazole/phenylpyrazole/organofluor ine insecticide; veterinary medicine. Fipronil was intro duced into the United States in 1996 for use in animal health and indoor pest control. It is the constituent of many products for controlling a wide spectrum of domestic ani mal and residential pests. Banned for use in EU. |
| Metabolic pathway | Through the abiotic degradation of fipronil in aqueous solution and on the soil surface, 5-amino-3- carbamoyl-1-[2,6-dichloro-4-(trifluoromethyl)-phenyl]-4- [(trifluoromethyl)sulfinyl]pyrazole is the only hydrolysis product detected. Fipronil in acidic aqueous solution exposed under a xenon lamp degrades with the concomitant appearance of 5-amino-3-cyano-1-[2,6- dichloro-4-(trifluoromethyl)-phenyl]-4- (trifluoromethyl)pyrazole and 5-amino-3-cyano-1-[2,6- dichloro-4-(trifluoromethyl)phenyl]pyrazole-4-sulfonic acid. Under field conditions, when fipronil is applied in formulation, four metabolites which include one product resulting from reduction on the sulfur atom of fipronil are detected. |
| Shipping | UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2902 Pesticide, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. |
| Degradation | Fipronil is stable in water at pH 5 and 7 but is slowly hydrolysed at pH 9 (DT50 28 days) to the amide (2). It undergoes rapid aqueous photolysis with a DT50 of <0.5 day. The major photodecomposition product in water and on soil surfaces is desulfinyl-fipronil(3) which is formed by extrusion of the SO group. A minor photoproduct in water, on soil and on plant surfaces is the sulfonic acid (4). The mechanisms of these reactions are discussed in a recent paper by Bobe et al. (1998). |
| Toxicity evaluation | Acute oral LD50 for rats: 100 mg/kg |
| Waste Disposal | It is the responsibility of chemical waste generators to determine the toxicity and physical properties and of a discarded chemical and to properly identify its classification and certification as a haz ardous waste and to determine the disposal method. United States Environmental Protection Agency guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult and fol low all regional, national, state and local hazardous waste laws to ensure complete and accurate classification and dis posal methods. |
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