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CAS 475207-59-1 Sorafenib Tosylate 200mg For Colon Cancer

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CAS 475207-59-1 Sorafenib Tosylate 200mg For Colon Cancer

CAS 475207-59-1 Sorafenib Tosylate 200mg For Colon Cancer
CAS 475207-59-1 Sorafenib Tosylate 200mg For Colon Cancer

Large Image :  CAS 475207-59-1 Sorafenib Tosylate 200mg For Colon Cancer Get Best Price

Product Details:
Place of Origin: China
Brand Name: germax
Certification: GMP
Model Number: Sorafenib Tosylate
Payment & Shipping Terms:
Minimum Order Quantity: 100 grams
Price: Negotiable
Packaging Details: 1kg/bag or 25kgs/drum
Delivery Time: within 3 days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500kgs/month
Detailed Product Description
Name: Sorafenib Tosylate Cas: 475207-59-1
Mf: C28H24ClF3N4O6S Content: 99%
Appearance: White Powder Package: 5kgs/bottle
Quality Standard: CP,USP
High Light:

CAS 475207-59-1 Sorafenib Tosylate


Colon Cancer Sorafenib Tosylate


Sorafenib Tosylate 200mg

Top Quality Sorafenib CAS 475207-59-1 Sorafenib Tosylate for Colon Cancer


Sorafenib tosylate

Product Name: Sorafenib tosylate
Synonyms: SORAFENIB TOSYLATE;Sorafenib & its intermediates;Sorafinib mesylate;4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate;Sorafenib Tosylate(Bay 43-9006,Nexavar);SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE);BAY 43-9006;BAY43-9006;4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-methylbenzenesulfonate)
CAS: 475207-59-1
MF: C28H24ClF3N4O6S
MW: 637.0265696
EINECS: 641-758-8

General Description:

Sorafenib is available in 200-mg tablets for oral administrationand is used in the treatment of RCC and colon cancer.The agent is classified as a multikinase inhibitor because ofits action on numerous kinase enzymes including thePDGF-R, VEGF-R, Kit, and Raf. Sorafenib is 39% to 48% bioavailable and CYP3A4-mediated metabolism giveseight identified metabolites including the N-oxide, which isequally active with the parent. However, the majority of thedrug in plasma is present as the parent compound.Sorafenib is highly protein bound (99.5%). The drug iseliminated primarily in the feces (77%) with 19% appearingin the urine as glucuronides (UGT1A1) and has a eliminationhalf-life of 24 to 48 hours. The most commonly seentoxicity is skin rash that normally occurs within the first6 weeks of therapy. Other adverse effects include hypertension,fatigue, increased wound healing time, and increasedrisk of bleeding.

Uses: An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases.



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