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Antineoplastic Drug Gefitinib Powder,
CAS 184475-35-2 Gefitinib Powder,
C22H24ClFN4O3 Gefitinib Powder
99% Antineoplastic Drug Gefitinib CAS 184475-35-2 with Best Price C22H24ClFN4O3
Product Name: Gefitinib
Synonyms: N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine Gefitinib;Gefitinib, >=99%;N-(3-Chlor-4-fluorophenyl)-7-[methoxy-6-[(3-morpholin-4-yl)propoxyl]-quinazolin-4-yl]amine;GEFITINIB RELATED COMPOUND;Gefitinib N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;IRESSA;GEFITINIB;n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Melting point: 119-120°C
Boiling point: 586.8±50.0 °C
Storage temp.: Store at RT
Geftinib is available as 250-mg tablets for oral administrationin the treatment of NSCLC for those patients who have failedto respond to platinum-based therapies and docetaxel and hasalso been used against squamous cell cancers of the head andneck. The agent is an inhibitor of the TK of EGF-R and possiblyother TKs as well.
Gefitinib is both a substrate and inhibitorof Pgp and BCRP. The agent is absorbed slowly afterbeing administered orally with 60% bioavailability.Metabolism occurs in the liver and is mediated primarily byCYP3A4 to give eight identified metabolites resulting fromdefluorination of the phenyl ring, oxidative-O-demethylation,and multiple products arising as a result of oxidation of themorpholine ring. The O-demethylated product represents thepredominate metabolite and is 14-fold less active comparedwith the parent. The parent and metabolites are eliminated inthe feces with a terminal elimination half-life of 48 hours.
The drug appears to be well tolerated with the most commonlyreported side effects being rash and diarrhea. It mayalso cause elevations in blood pressure especially in those patientswith preexisting hypertension, elevation of transaminaselevels, and mild nausea and mucositits.
Gefitinib is an antineoplastic.
|Name: gefitinib||Precise quality: 446.152100|
|Destiny: 1.3±0.1 g/cm3||PSA : 68.74000|
|Boiling point: 586.8±50.0 °C at 760 mmHg||LogP: 4.11|
|Melting point: 119-1200C||Appearance: White powder|
|Molecular formula: C22H24ClFN4O3||Vapour pressure: 0.0±1.6 mmHg at 25°C|
|Molecular weight: 446.902||Refractive index: 1.621|
|Flashing point: 308.7±30.1 °C||
Water solubility: /
Contact Person: July