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Antineoplastic Drug Gefitinib Powder CAS 184475-35-2 C22H24ClFN4O3

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Antineoplastic Drug Gefitinib Powder CAS 184475-35-2 C22H24ClFN4O3

Antineoplastic Drug Gefitinib Powder CAS 184475-35-2 C22H24ClFN4O3
Antineoplastic Drug Gefitinib Powder CAS 184475-35-2 C22H24ClFN4O3

Large Image :  Antineoplastic Drug Gefitinib Powder CAS 184475-35-2 C22H24ClFN4O3 Get Best Price

Product Details:
Place of Origin: China
Brand Name: germax
Certification: GMP
Model Number: Gefitinib
Payment & Shipping Terms:
Minimum Order Quantity: 100 grams
Price: Negotiable
Packaging Details: 1kg/bag or 25kgs/drum
Delivery Time: within 3 days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500kgs/month
Detailed Product Description
Name: Gefitinib Cas: 184475-35-2
Mf: C22H24ClFN4O3 Content: 99%
Appearance: White Powder Package: 5kgs/bottle
Quality Standard: CP,USP
High Light:

Antineoplastic Drug Gefitinib Powder


CAS 184475-35-2 Gefitinib Powder


C22H24ClFN4O3 Gefitinib Powder

99% Antineoplastic Drug Gefitinib CAS 184475-35-2 with Best Price C22H24ClFN4O3

Product Description

Product Name: Gefitinib
Synonyms: N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine Gefitinib;Gefitinib, >=99%;N-(3-Chlor-4-fluorophenyl)-7-[methoxy-6-[(3-morpholin-4-yl)propoxyl]-quinazolin-4-yl]amine;GEFITINIB RELATED COMPOUND;Gefitinib N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;IRESSA;GEFITINIB;n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
CAS: 184475-35-2
MF: C22H24ClFN4O3
MW: 446.9
EINECS: 643-034-7
Melting point: 119-120°C
Boiling point: 586.8±50.0 °C
Storage temp.: Store at RT


Geftinib is available as 250-mg tablets for oral administrationin the treatment of NSCLC for those patients who have failedto respond to platinum-based therapies and docetaxel and hasalso been used against squamous cell cancers of the head andneck. The agent is an inhibitor of the TK of EGF-R and possiblyother TKs as well.

Gefitinib is both a substrate and inhibitorof Pgp and BCRP. The agent is absorbed slowly afterbeing administered orally with 60% bioavailability.Metabolism occurs in the liver and is mediated primarily byCYP3A4 to give eight identified metabolites resulting fromdefluorination of the phenyl ring, oxidative-O-demethylation,and multiple products arising as a result of oxidation of themorpholine ring. The O-demethylated product represents thepredominate metabolite and is 14-fold less active comparedwith the parent. The parent and metabolites are eliminated inthe feces with a terminal elimination half-life of 48 hours.

The drug appears to be well tolerated with the most commonlyreported side effects being rash and diarrhea. It mayalso cause elevations in blood pressure especially in those patientswith preexisting hypertension, elevation of transaminaselevels, and mild nausea and mucositits.


Gefitinib is an antineoplastic.



Name: gefitinib Precise quality: 446.152100
Destiny: 1.3±0.1 g/cm3 PSA : 68.74000
Boiling point: 586.8±50.0 °C at 760 mmHg LogP: 4.11
Melting point: 119-1200C Appearance: White powder
Molecular formula: C22H24ClFN4O3 Vapour pressure: 0.0±1.6 mmHg at 25°C
Molecular weight: 446.902 Refractive index: 1.621
Flashing point: 308.7±30.1 °C

Water solubility: /





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