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|Appearance:||White Powder||Packing:||1kg/Bag,10kg/Drum,25kg/Drum Or As Required|
Anti Inflammatory Tacrolimus Powder,
C44H69NO12 Tacrolimus Powder,
99.5% Purity White Tacrolimus Powder
Tacrolimus Powder for Anti-Inflammatory Manufacture Tacrolimus CAS 104987-11-3 Safety Delivery
Tacrolimus CAS: 104987-11-3
Tacrolimus MF: C44H69NO12
Tacrolimus MW: 804.02
Tacrolimus Product Categories:Pharmaceuticals;Chiral Reagents;Fujimycin, Prograf;antibiotic
Tacrolimus Chemical Properties: White Crystalline Solid
Tacrolimus Usage: An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
"Tacrolimus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.
Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
|Description||A white or off-white crystalline powder||Conform|
|Identification||1. IR (USP <197K>)||Conform|
|2. HPLC retention times||Conform|
(USP <921> Method I)
|1.6 ~ 3.0%||2.1%|
|Residue on ignition
(USP <231> II)
|£ 20 ppm||< 20 ppm|
|Related substances (In-house HPLC method)||Ascomycin £ 0.8%||0.064%|
|Acetone £ 2000 ppm||Not detected|
|Assay (on anhydrous basis)||98.0% ~ 102.0%||100.0%|
|Conclusion: Complied with In-House standard
Contact Person: July