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Name: | Tacrolimus | CAS: | 104987-11-3 |
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Purity: | 99.5% | MF: | C44H69NO12 |
Appearance: | White Powder | Packing: | 1kg/Bag,10kg/Drum,25kg/Drum Or As Required |
High Light: | API Tacrolimus Powder,CAS 104987-11-3 Tacrolimus Powder,Tacrolimus Monohydrate |
Best Price API Raw Material 99% CAS 104987-11-3 Tacrolimus Monohydrate Tacrolimus Powder
Product Name | Tacrolimus |
Alias | Tsukubaenolide Hydrate |
CAS | 109581-93-3 |
MF | C44H69NO12 |
MW | 804.02 |
Grade | Pharmaceutical Grade |
Appearance | White To Light Yellow Crystal Powder |
Description:
Tacrolimus is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease and the skin condition vitiligo.
Usage:
Pharmaceutical raw materials; It is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease, and the skin condition vitiligo.
Test:CAS: 104987-11-3 Tacrolimus
ANALYSIS | SPECIFICATION | RESULTS |
Appearance | White powder | Complies |
Assay (HPLC) | ≥98% | 98.5% |
Sieve analysis | NLT 95% pass 80 mesh | Complies |
Loss on Drying | ≤2.0% | 1.95% |
Ash | ≤5.0% | 2.15% |
Pb | <2ppm | Complies |
As | <2ppm | Complies |
Hg | <2ppm | Complies |
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug.It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
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