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HPLC Test CAS 53123-88-9 Rapamycin Powder C51H79NO13

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HPLC Test CAS 53123-88-9 Rapamycin Powder C51H79NO13

Name: HPLC Test CAS 53123-88-9 Rapamycin Powder C51H79NO13
Brand: germax
SKU: Rapamycin
Price: 1.00 USD
Availability: InStock
Rating: 4.6 (198 reviews)

Large Image : HPLC Test CAS 53123-88-9 Rapamycin Powder C51H79NO13 Get Best Price

Product Details:

Place of Origin:	China
Brand Name:	germax
Model Number:	Rapamycin

Payment & Shipping Terms:

Minimum Order Quantity:	10 gram
Price:	Negotiable
Packaging Details:	10g/bottle ,50g/bottle , 100g/bag ,1kg/bag
Delivery Time:	within 3 days
Payment Terms:	T/T, Western Union, MoneyGram
Supply Ability:	2000 grams/month

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Detailed Product Description

Name:	Rapamycin	CAS:	53123-88-9
Purity:	99.5%	MF:	C51H79NO13
Appearance:	White Powder	Packing:	1kg/Bag,10kg/Drum,25kg/Drum Or As Required
High Light:	CAS 53123-88-9 Rapamycin Powder , C51H79NO13 Rapamycin Powder , HPLC Rapamycin Powder

Factory Supply CAS 53123-88-9 Rapamycin Powder with Best Price Rapamycin high quality

Product Name	rapamycin
Appearance	white crystalline powder
Assay	99%min rapamycin powder
Test	HPLC
Certificate	ISO 9001
CAS	53123-88-9
MF	C51H79NO13
Einecs No	262-640-9
Storage Temperature	Keep in a cool, dry, dark location in a tightly sealed container or cylinder.

What is rapamycin powder?

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor.
Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases,which have PI 4-kinase and

autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity,but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. Rapamycin also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.

Function of Rapamycin 53123-88-9

Rapamycin is a triene macrolide antibiotic,which demonstrates anti-fungal,anti-inflammatory,anti-tumor and immunosuppressive properties.
Rapamycin has been shown to block T-cell activation and proliferation,as well as,the activation of p70 S6 kinase and exhibits strong binding to FK506 binding proteins.
Rapamycin also inhibits the activity of the protein,mTOR(mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth.
Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.

Application of Rapamycin 53123-88-9

Rapamycin (RAPA) is a novel macrolide immunosuppressant is now often used as a transplanted organ to maintain immunity drugs (especially kidney transplants), to mitigate the immune organ rejection after transplant surgery, but scientists it recently found another purpose: for the treatment of Alzheimer's disease (senile dementia).

Target of rapamycin (mTOR) as an intracellular kinases pathway abnormalities can induce a variety of diseases. As rapamycin mTOR inhibitor targeting, to treat with this pathway is closely related to tumors, including renal cell carcinoma, lymphoma, lung cancer, liver cancer, breast cancer, neuroendocrine carcinoma and gastric cancer

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