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Good Quality Pyrimethamine CAS 58-14-0 for Antiprotozoal

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Good Quality Pyrimethamine CAS 58-14-0 for Antiprotozoal

Good Quality Pyrimethamine CAS 58-14-0 for Antiprotozoal
Good Quality Pyrimethamine CAS 58-14-0 for Antiprotozoal

Large Image :  Good Quality Pyrimethamine CAS 58-14-0 for Antiprotozoal Get Best Price

Product Details:
Place of Origin: China
Brand Name: germax
Certification: GMP
Model Number: Pyrimethamine
Payment & Shipping Terms:
Minimum Order Quantity: 100g
Price: Negotiable
Packaging Details: 1kg/bag or 25kgs/drum
Delivery Time: within 48 hours after get the payment
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500kgs/week
Detailed Product Description
Name: Pyrimethamine CAS: 58-14-0
Form: White Crystalline Powder Content: 99%
Min Order: 100g Molecular Formula: C12h13cln4
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Pyrimethamine for Antiprotozoal


CAS 58-14-0 purity 99% Powder


C12H13ClN4 top quality

Good Quality Pyrimethamine CAS 58-14-0 for Antiprotozoal



Product Name: Pyrimethamine
Synonyms: 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;[2-amino-5-(4-chlorophenyl)-6-ethyl-pyrimidin-4-yl]amine;Pyrimethamine,5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;Pyrimethamine (200 mg);PyriMethaMine,darapriM;5-(p-chlorophenyl)-6-ethyl-4-pyrimidinediamine;BW 50-63;bw50-63
CAS: 58-14-0
MF: C12H13ClN4
MW: 248.71
EINECS: 200-364-2
Melting point: 233-234°C
Boiling point: 393.35°C
Storage temp.: 0-6°C


Pyrimethamine is a diaminopyrimidine which is structurally related to trimethoprim. It is effective against erythrocytic stage of Plasmodium (P) falciparum and less so against P. vivax, P. ovale and P. malariae. Pyrimethamine also inhibits the sporogony in the mosquito, resulting in a decrease of transmission of the infection within the community.
The mechanism of action of pyrimethamine is related to its inhibition of dihydrofolic reductase necessary for the folic acid synthesis in the parasite. Pyrimethamine acts slowly and is not recommended as monotherapy for acute malaria attacks. Resistance to pyrimethamine developed soon when the drug was used on a large scale as monoprophylaxis. In resistant strains, the enzyme dihydrofolic reductase binds to pyrimethamine several hundred times less than in sensitive strains. This high grade resistance is probably a onestep mutation and cannot be overcome by increasing the dose. However, when combined with long-acting sulphonomides (sulphadoxine), the effect of pyrimethamine is potentiated and the risk of developing resistant strains is far less.


Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial



Item name Standard
Characteristics White or off white powder
Identification Positive
Clarity and color of solution 2.5% W/V mixed solution is clear; color≤BY6
Acidity and alkalinity Requires 0.01M sodium hydroxide VS not more than 0.2ml and 0.01M hydrochloric acid VS not more than 0.4ml
Related substances Any second spot in solution 1.0% W/V is not more than 0.25%
Sulphate ≤80ppm
Melting point 238-242ºC
Loss on drying ≤0.50%
Ash ≤0.1%
Assay(on dry basis) 99.0-101.0%




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