Lederfen CAS :36330-85-5 Formula :C16H13O3 chemical China manufacturer

Products details:

Other name: 4-(4-Biphenyl)-4-oxobutyric acid
CAS NO.: 36330-85-5
EINECS NO.: 252-979-0
MW: 254.28
MF: C16H14O3
InChI: 1/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)/p-1
Melting point: 185-187ºC
Boiling Point: 470.2°C at 760 mmHg
Flash Point: 252.3°C
Appearance: white or Off-white powder
Standard: USP/BP/CP/EP

Product Description
Fenbufen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives class.
It was introduced by American Cyanamid under the trade name Lederfen in the 1980s and was withdrawn from markets in the developed world due to liver toxicity in 2010.:370, 383-384.As of 2015 is was available in Taiwan and Thailand under several brand names.
As a relatively new type of long-term non-steroidal anti-inflammatory and analgesic drug. According to animal studies, although the anti-inflammatory and analgesic action of this crystal was lower than those of indomethacin, but stronger than aspirin. Toxicity is smaller than indomethacin, gastrointestinal side effects than aspirin and other non-steroidal anti-inflammatory and analgesic drug. The pharmacological research showed that the crystal in the body metabolism into PCB ethyl ester, which inhibits the synthesis of prostaglandins, thereby blocking the role of inflammatory mediators, think this is this article main mechanism of anti-inflammatory effects. Finn cloth as a precursor of biphenyl ethyl ester, can avoid taking active metabolites directly after oral stimulation of the gastrointestinal tract. The domestic trial in rheumatoid arthritis, rheumatoid arthritis, the total effective rate was 87%. This drug is generally can make the chain of rheumatoid factor, blood sedimentation, turn back to normal or "O" and other indicators. Pathological examination did not see the main viscera have obvious pathological changes. Two hours after the oral blood concentrations of peak value. T 1/2 for 12 ~ 17 hours. Used for rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout treatment, etc. Also used for toothache, pain pain after surgery, trauma, pain, etc.